See I’ve never understood why people obsess about living longer. All those extra years come at the end, which is the adult diaper, memory loosing, decrepit part of life. It doesn’t stretch out the younger good parts, it just staves off death during the miserable part. Personally I’d rather just get it over with sooner with a nice, quick aneurysm in my sleep.
More years usually = more healthy years, that’s how you end up with more years. Chronic disease wears bodies out faster, not more slowly. I’d rather get it over later, and yes with something quick.
Sure there will come a time when I am uncomfortable every day but at near 60 still do yoga, eat well, sex every day, nothing hurts, very good quality of life. Didn’t expect it but I have it for now.
Sex every day? U lucky bastid
i’ve never understood the western obsession with equating the pursuit for immortality with vanity. you tell me you hear you’re gonna die one day, lights out and that’s it no more you forever, and you don’t even have just a little thought in the back of your mind, constantly begging a solution to the inevitable?
Nope.
Why beg for something that is impossible and likely to add to my pain later in life? I see no reason to hold onto that dream or to beg for it.
I don’t understand what is worth sticking around indefinitely for either when it’s the fact that the present is slipping by so quickly for so many. You don’t get it back for living longer.
I have the opposite little thought in the back of my mind. Knowing that my life will end one day gives me the energy to keep going. If I had to live forever, I would need a few 100 year naps or I’d go insane.
Like if I die and “wake up” in the afterlife and I gotta keep existing. Fuck that. Send my energy back to the source and let it just vibrate.
The longer you live, the closer you get to downloading your brain into a clone body
They’re talking about stretching out the whole ageing process. So if you live longer you also grow old more slowly.
Rats average lifespan is 3 years, but that doesn’t mean they are really healthy, and then just drop dead, they go through the ageing process at a hyper-accelerated rate. Equally if humans had a lifespan of 120 years the old age part would move to around the 100 years mark, you wouldn’t start getting old at 60 and then just be geriatric for the next 60 years.
This misconception is why I and many others prefer the precise wording: gaining healthy(ish) years.
You don’t die of ‘old age’. You die of disease(s), which become more and more likely as you accrue damage throughout your life. You can’t really extend the period someone stays alive with end stage dementia or cancer. If anything, you can only prevent, halt, or slow the development of the diseases. And that’s what’s meant by longevity/extending life.
Granted, you’ll still accumulate non fatal issues. But I’d argue you can lead a meaningful life with knee pain and far sightedness.
But I’d argue you can lead a meaningful life with knee pain and far sightedness.
My back started hurting at 25, I hadn’t even had a job yet.
That sucks! Mine started hurting at 27 (this year). My knees started hurting it around 16. I dont think I should want to die due to this.
Enough quality of life to continue shitposting.
should really source the science paper, it came from then a site like vice.
Be the change you want to see…
To evaluate the impact of psilocybin on longevity in vivo, aged (19 month) female mice were treated with vehicle [vehicle is what the psilocybin was suspended in for injection] or psilocybin [actually vehicle + psilocybin] once/month for 10 months; mice were initially given a low-dose (5 mg/kg) for the first treatment followed monthly high-dose (15 mg/kg) treatment for a total of 10 treatments. We elected to utilize 19-month old mice, which is roughly equivalent to 60–65 human years, in order to evaluate its therapeutic potential as a clinically-relevant anti-aging intervention.
Within 30 min post-treatment, mice exhibited increased head-twitch response, which is a well-established behavioral indicator of hallucinogenic impacts of psilocybin in mice. Both psilocybin and vehicle groups exhibited some loss in body weight from the start to end of the treatment protocol, however weight loss was not significantly different in vehicle vs. psilocybin-treated mice. Notably, psilocybin treated mice demonstrated significantly higher survival (80%), compared to vehicle (50%).
Although not quantitatively measured, psilocybin-treated mice exhibited phenotypic improvements in overall fur quality, including hair growth and reductions in white hair compared to vehicle-treated mice.
In summary, we provide the first experimental evidence demonstrating that psilocybin treatment can enhance survival in aged mice.
So, caveats:
- This is the first study; while further studies may show a similar result, we won’t know for sure until they are completed. This could be a fluke. This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
- This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
- Typical doses for psilocybin are 0.2–0.4 mg/kg in therapeutic settings, 4mg/kg for microdosing, to up to 20 mg/kg to be legitimately tripping; like the mice, if you use this regimen you will need to set aside a day to be tripping once a month, and after 10 months take a heroic dose and have a really big trip. Not impossible to arrange for many people, but this is not a regimen you can do while completely going about your regular day-to-day.
TLDR: Promising results in an under studies area. More studies are required to confirm results. Following this regimen will cause a non-trivial disruption in your monthly routine.
Upside: live 50 years longer
Downside: spend it staring at your hands
At least then I wouldn’t be doom scrolling I guess.
My hands are fuckin awesome. Sign me up
better than my day to day
Oh thank god. I thought it was diet and exercise so this comes as a huge relief.
If you ever talk to anyone over the age of 100 every single one of them without fail, swears that the secrets to long life is brandy and cigarettes.
Either they’re really on to something or they’re trying to kill everyone else off.
I looked into genetic factors of centurions out of curiousity before and it does largely seem to be nature rather than nurture. Centurions tend to have siblings that are also centurions, both of whom typically have overactive telomerase enzymes. Apparently some type of enzyme that prevents aging of cells. Theoretically, if those same people avoided alcohol and cigs their whole life, they would have lived even longer.
technically still diet
Cant wait for this to be exploited by the rich and still be illegal for the poor
still need someone to explain me why a chemical that can make people happy has to be illegal.
if there are also very dangerous, I get it. but if the risk is taking a long nap and changing your mind. then why would the government care?
The (US) government has a long history of outlawing useful, helpful or otherwise enjoyable things (MDMA, weed and psilocybin) while allowing more destructive things to proliferate (alcohol, opiates). Many governments worldwide still outlaw marijuana and some places will straight up execute people for it (singapore). Keeps the population in check and helped fuel conflict within the lower class to keep them from looking upward.
Banning alcohol was already tried and it turned out to be a really bad idea.
In contrast, the War on Drugs has gone just super great.
It’s not difficult to say, allow nature to do its thing and allow cubensis to grow naturally, in a shoebox.
Maybe they learn some empathy
Their brains are literally wired wrong. They will not learn empathy, but assume they are capable of more than they are.
They’re evil; not biologically different. You too could be an evil rich fuck, but instead you’re just a stupid poor fuck.
Some are biologically (that is, neurostructurally and neurochemically) different as a result of genetics. This is one of the key differences between psychopathy and sociopathy, as a matter of fact, in terms of the root cause of the condition.
I’ve partied with scientists so I’m not surprised
Scientists are just cool like that
Oh look, it’s vice.com, so presumably these ‘scientists’ are from the University of Joe Rogan or U of Y(outube) or something.
They do link to the actual study, which does not throw up any immediately obvious signs to be cautious for me, but I also couldn’t do the detailed work of deeper research myself. They reference a hypothesis that preceded the study, which they were trying to test with this. I don’t know if this is a case of bias or even manipulation at work, but at least at a superficial glance, it doesn’t immediately scream “total hacks doing unscientific things.”
Good news, they find a treatment regimen that when applied to mice cause them to have a health span several times longer than the average health span of a mouse.
Bad news, the treatment regimen when applied to humans causes them to have a health span several times longer than the average health span of a mouse.
Twist: It was all relative to the life span of a lab mouse, whos life is a living hell in nine out of ten cases.
Meaning… the results will only confirm that there are controlling substances that will allow a populace to endure literal torture, and enable the rich to literally take over the world NOT for efficacy but for sheer chemical complacency.
Please be a “yes,” please be a “yes…”
Edit: WOO! It’s a "looks that way in cell cultures so far!"🥳
I haven’t gone looking forthe souce paper, but from the article it looks like seretonin was the actual compound that’s having a beneficial effect, specifically serotonin outside the brain.
So how is a psychedelic pulling this off? The secret could be serotonin receptors found throughout the body, not just in the brain. When activated, they seem to trigger a cascade of effects that reduce stress, preserve DNA, and promote long-term cell health.
They’re talking about psilocin’s activity at serotonin receptors, I’m pretty sure
It’s a bit ambiguous, so you could be right, but I took it to mean that activation of the receptors was that active mechanism, regardless of cause. Psilicin is just the compound they’re focused on, and maybe it does activate them in some unique way that has this effect, but the summary didn’t make that clear.
If there are alternative pathways to activate the receptors they may be better suited to thereputic use without the psycadelic side effects.
Sure just take the fun out of it why don’t you
If you do happen to find it, please post a link. I’ll go looking also.
Never mind. It was linked in the article.The paper in question.
Oooh, yeah… reread it more carefully… wellp! At least we do get some of that from 'shrooms!:))) Partial win!:)))
Who the fuck wants to live longer?
Me. I want to see more sunrises.
i want to outlive the last fascist
You don’t have to live longer, just make it happen sooner
that’s where the workouts enter the picture
don’t fight fire with fire.
fight fire by erecting as many dams and walls as can be reasonably constructed and then go hide in a bunker or under the roots of the yggdrasil tree or sth please
When I see this regime and the new plane trump is going to get I am not reminded of the abandoned Soviet shuttle and realize that no “great” things last and one day his plane will be sitting in a warehouse falling apart and gathering dust
Me. I want to see us get serious about fighting global warming, so I know I’m leaving my kids a better world
Slowing cell aging could mean better health for longer, even if you don’t die (much) later.
living longer is often correlated with staying healthy for longer, and that’s a nice thing i guess
Well, I’m definitely going to stop then.
Turns out Melange was on Earth this whole time.
