Cambridge researchers have shown how commonly-used sweeteners slow the growth of certain gut bacteria. Isosteviol – a compound derived from stevia (a common sweetener) – when combined with the anti-depressant duloxetine significantly impaired two important gut bacteria linked to regulating blood sugar and gut health and may affect the body’s immune responses.
  • Atelopus-zeteki@fedia.io
    3·
    3 days ago

    SYAC: Isosteviol (derived from Stevia rebaudiana) and duloxetine (Cymbalta, Drizalma Sprinkle). Though it’s more complicated than that.

    Common xenobiotics modulate gut microbial responses to low‑calorie sweeteners in vitro https://link.springer.com/article/10.1038/s44320-026-00225-6

    Low-calorie sweeteners and their combinations with co-consumed xenobiotics were tested in vitro for direct effects on gut bacteria.

    30 interactions discovered between sweeteners and gut bacteria.

Sweeteners show synergistic and antagonistic interactions with xenobiotics like antidepressant duloxetine.

Multi-omics analyses reveal key role of transporters.

Altered bacterial secretome impact cytokine response of human cells.