I typically prefer subbed; watching dubbed feels off somehow. Then again, I’m perfectly fine with the dubbing in DBZA so it must be a preference I learned somewhere!

Ahhhh fair play. I have a lot of freedom since I’m paying out of pocket for my own use. I have a pretty beefy rig for running local, but it’s not beefy enough to run deepseek pro and the like 😬 so, I have a bunch of subscriptions to try out a bunch of different models and see what works best in my workflow. I also have a problem with making alts in games, which seems like it rhymes 🤔

Been pretty impressed with glm5.1 too, before deepseek-v4 came out, but you’d be amazed what even a smaller older coding model can do with the right config and a little proactive context management. I really hope this trend of smaller, better models for local agentic use continues.

I’ve been using deepseek v4 flash on opencode’s infra for a couple of weeks and it’s pretty solid for something so low-cost. Honestly satisfied with it over Claude, for the premium Anthropic charges. Have you tried it at all?

Until we get to the total plan limits. They don’t cover costs to infinity, you know. And for something like cancer treatment, most plans don’t actually offer enough coverage to sustain it for years, so you’re still on the hook for tens or hundreds of thousands of dollars after all is said and done.

No, that guy holding a swastika flag at a Nazi march isn’t a Nazi. You don’t know anything else about him!

I don’t need to, though - and now, I don’t need to know anything else about the guy who said that, either.

I hate how transparent and low-effort your trolling is. Yes, there are Nazis in Ukraine. They’re not in power, and it still doesn’t justify Russia’s unprovoked war of aggression.

Now, before you spout off about literally anything else to avoid addressing that point: don’t bother. Instead, try harder. We’ll still see you for what you are, but at least it might be more of a challenge and you might experience some character growth along the way.

Why didn’t the person that died just not die? Are they stupid?

• A person who was not there and did nothing to help

The amyloid hypothesis has been supported by fraud for 20 years.

Pharma made drugs that dropped amyloid by 30% and they do NOTHING despite FDA approvals.

Okay, got any sources for that, or should we take you at your word?

Mouse models do not get dementia.

I don’t believe I said they did. Why the confrontational tone?

Misleading headline. What they actually demonstrated is reversing amyloid accumulation and the cognitive deficits in a transgenic mouse whose pathology is essentially just amyloid accumulation. Calling that “reversing Alzheimer’s” treats amyloid buildup and the disease as the same thing, which is exactly the conflation the amyloid hypothesis has been criticised for over the last decade.

Alzheimer’s in humans is amyloid + tau tangles + neuroinflammation + vascular dysfunction + actual neurodegeneration (entorhinal and hippocampal neurons dying, brain volume measurably dropping on MRI). Tau burden correlates with cognitive decline far better than amyloid does. The IBEC paper addresses one of those layers, the upstream-ish one, in a model that doesn’t reproduce most of the others. Fixing a cause in a young system before damage has accumulated is just not the same operation as fixing an established disease in an old human cortex that’s already lost the cells.

The human translation data backs this up. Lecanemab clears plaques and slows cognitive decline by about 27% over 18 months. Donanemab clears around 76% of plaques and slows decline by ~35% in early AD. In both trials both arms still declined, treatment just declined a bit more slowly. Northwestern’s Mesulam Institute puts it bluntly: “These medications do not reverse existing disease or stop the progression.” So removing amyloid in a system that already has the full human pathology bends the curve, it doesn’t undo anything.

What the IBEC team has here is a genuinely interesting result for the cerebrovascular angle, where BBB dysfunction and glymphatic clearance failure are upstream of plaque accumulation rather than a downstream consequence. The LRP1 transport mechanism and the multivalent ligand design are clever and well-grounded. The fair claim is “we improved amyloid clearance and rescued behavioural deficits in an amyloid-overexpressing mouse by targeting BBB transport.” That’s a real contribution. “Reversed Alzheimer’s” sells the mechanism by overstating what it did, and it sets up the same disappointment cycle the field has been through with every other anti-amyloid intervention that worked great in mice.

Original paper, for anyone wanting the actual data: https://doi.org/10.1038/s41392-025-02426-1

I am not patronising and that was not my intent. Read whatever you want into it of course, I can’t stop you.

Well, sure, and I appreciate your sanguinity haha! I just main support, and felt your question deserves a proper answer.

I am planning on answering when I’m at a computer, as well, because I actually do have a matrix server set up with Synapse and MAS. Quick question though, when you ask how it works, do you mean the actual backend, or are you asking if the performance/user experience is good?

Don’t get me wrong, suggestions are appreciated, but you’re answer is absolutely typical of a Stack overflow “huhuh well don’t do it wrong then” comment. You could have, for example, said you don’t use Synapse but this is why you like Continuwuity. (edit: not prescribing speech, giving an example of how your comment could have read better)

As well, I take issue with the idea that people can only ask for help in sanctioned forums. This is a self-hosting community, after all; I am here not only to learn but to share what I learn, which I thought was the whole point.

What is this, StackOverflow? You didn’t answer their question and instead just told them to use a different solution.

What gives you’re instance of anything any importance.

As in, why would anyone sign up on my instance? Why would anyone come see my content?

Answer me this: Why would they have to sign up, or come to my instance, to see my content? If I’m not broadcasting objectionable shit, my instance will remain federated, so everyone will see posts from me and my instance on their preferred instance. And I’ll see all their content, on my own instance.

The problem you’re imagining is already solved. Even if a big popular instance gets bought, or taken over by fiat, defederation works as a solution; the content is posted by users, so there’ll just be an explosion of content from a different instance as everyone moves.

Ah, I’ll put in a zoom feature, that’s a good idea!

Remind me of the hardware you’re running on? 22 hours for a 4k HDR movie sounds about in the ballpark for converting on CPU. I’ve just switched to Linux (Mint, not Cachy) and I think there’s an issue with detecting GPU on Linux, so this’d track (or you have Precision Mode enabled) - if you see “libx265” or “libx264” in the top right, you’re on CPU. I’m looking into this one.

Can I ask which version you downloaded? I’ll look into the DVTools/MP4box issue.

Also, yes, I removed the codec and container selection boxes - it’s HEVC/MKV by default unless you go for “Compatibility Mode” in which case you get H.264/MP4. “Preserve AV1” of course preserves AV1 which is incompatible with MP4 so they’re mutually exclusive.

So… How’s it working? 😅 (Just realised it’s been a while since I’ve touched HISTV and this came to mind, I’ve been working on my business and day job)

Ah, what version did you try? This is due to issues with the renderer, but I just got this fixed by disabling GPU drawing for the form last night. Give 2.5.9 a go 😊

Hey, I haven’t made a full post about this yet, but I thought you’d like to know: v2.5.0 is out, and it implements quietvoid’s tools for DoVi support! https://github.com/obelisk-complex/histv-universal/releases

It’ll even handle DV 5 and 7 😊

Yes, it does imply it. It’s the most common association for mushroom clouds in our media since the bombs were dropped. Doesn’t guarantee it of course, but to act as though “they’re unrelated and anyone making the association is ignorant” would be an indefensible position.

Sweet as, lmk if you have any questions or run into any issues! 😊